Predictors of venous thromboembolism among infants in children’s hospitals in the United States: a retrospective Pediatric Health Information Study
- 16 October 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Perinatology
- Vol. 42 (1), 103-109
- https://doi.org/10.1038/s41372-021-01232-1
Abstract
Objectives Examine: (1) Prevalence of diagnosed venous thromboembolism (VTE) in infants <6 months discharged from U.S. NICUs; (2) Associations between sociodemographic and clinical factors and VTE; (3) Secondary outcomes related to VTE. Study design Multivariable logistic regressions examined associations between VTE and sociodemographic and clinical factors among infants <6 months discharged from Pediatric Health Information System (PHIS) NICUs between 2016 and 2019. Results Of 201,033 infants, 2720 (1.35%) had diagnosed VTE. Birthweight 300–1000 g (aOR 3.14, 95% CI 2.54–3.88), 1000–1500 g (aOR 1.77, 95% CI 1.40–2.42) versus 2500–3999 g, and public (aOR 1.18, 95% CI 1.02–1.37) versus private insurance were associated with increased odds of VTE, as were CVC, TPN, mechanical ventilation, infection, ECMO, and surgery. All types of central lines (non-tunneled and tunneled CVCs, PICCs, and umbilical catheters) had higher odds of VTE than not having that type of line. CVCs in upper versus lower extremities had higher odds of VTE. Conclusion Infants with risk factors may require monitoring for VTE. Results may inform VTE prevention.Keywords
This publication has 33 references indexed in Scilit:
- Trends in Venous Thromboembolism-Related Hospitalizations, 1994–2009PEDIATRICS, 2012
- Derivation and Validation of a Simple Model to Identify Venous Thromboembolism Risk in Medical PatientsThe American Journal of Medicine, 2011
- Pediatric venous thromboembolism in the United States: A tertiary care complication of chronic diseasesPediatric Blood & Cancer, 2011
- Predictive value of pediatric thrombosis diagnoses in the Danish National Patient RegistryClinical Epidemiology, 2010
- Dramatic Increase in Venous Thromboembolism in Children's Hospitals in the United States From 2001 to 2007PEDIATRICS, 2009
- Risk factors for umbilical venous catheter‐associated thrombosis in very low birth weight infantsPediatric Blood & Cancer, 2008
- Percutaneously Inserted Central Catheter for Total Parenteral Nutrition in Neonates: Complications Rates Related to Upper Versus Lower Extremity InsertionPEDIATRICS, 2008
- Association between thrombosis and bloodstream infection in neonates with peripherally inserted cathetersThrombosis Research, 2008
- Administrative Databases Provide Inaccurate Data for Surveillance of Long-Term Central Venous Catheter-Associated InfectionsInfection Control & Hospital Epidemiology, 2003
- Development of the Hemostatic System in the Neonate and Young InfantJournal of Pediatric Hematology/Oncology, 1990