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HPLC Method Validation for Determination of Pentoxifylline in Pharmaceutical Dosage Forms

Nasser Thalaj

Abstract: A selective and simple reversed phase High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for quantification of pentoxifylline in dosage forms available in local market. Firstly, different chromatographic conditions were tested. Then, the optimized method was validated. The method proven to be linear over 50% to 150% of the nominal concentration of standard pentoxifylline (R2 0.994). The method was accurate (recovery 100.1%) and precise (RSD% <3%). The method could separate pentoxifylline of caffeine and degradation products. The method was suitable for routine analysis of pentoxifylline in tablet dosage forms.
Keywords: optimized / pentoxifylline / Chromatography / tablet / routine / Pharmaceutical / RSD / quantification / reversed

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