Antiasthma Activities of Moringa oleifera Lam. Leaves Extract on the Eosinophil Count and Mast Cells in BALB/c Mice
Open Access
- 30 August 2021
- journal article
- Published by Universitas Muhammadiyah Palangkaraya in Borneo Journal of Pharmacy
- Vol. 4 (3), 171-177
- https://doi.org/10.33084/bjop.v4i3.1916
Abstract
Asthma is a chronic inflammation of the respiratory tract. This study aimed to prove Moringa oleifera Lam. leaves extract's effect on reducing the eosinophil count and mast cells in asthmatic mice. Twenty BALB/c mice that met the inclusion criteria were divided into four groups of standard control (K1), negative control (K2), dexamethasone (K3), and M. oleifera leaves extract (K4). On days 0 and 7, intraperitoneal ovalbumin (OVA) was sensitized. On days 14, 16, and 18, mice were re-sensitized by inhalation using 1% OVA in sterile 0.9% NaCl. On days 18 to 25, K1 and K2 groups were given Na-CMC, the K3 group was given dexamethasone 1.3 µg/day, and the K4 group was given M. oleifera leaves extract 3.9 mg/day. On the 25th day, the mice were terminated to analyze the eosinophil count and stable bronchiolar mast cells. In conclusion, M. oleifera leaves extract was proven to decrease the eosinophil count with a p-value <0.05 and could stabilize bronchiolar mast cells with a p-value <0.05.Keywords
This publication has 31 references indexed in Scilit:
- Mast Cell: A Multi-Functional Master CellFrontiers in Immunology, 2016
- Sleeping position and reported night-time asthma symptoms and medicationPan African Medical Journal, 2016
- Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animalsJournal of Basic and Clinical Physiology and Pharmacology, 2015
- Type 2 inflammation in asthma — present in most, absent in manyNature Reviews Immunology, 2014
- Health Benefits of Moringa oleiferaAsian Pacific Journal of Cancer Prevention, 2014
- Asthma: pathophysiology, diagnosis and managementNursing Standard, 2011
- Retro-orbital injections in miceLab Animal, 2011
- Investigation Into the Mechanism of Anti-Asthmatic Action ofMoringa oleiferaJournal of Dietary Supplements, 2009
- Antiasthmatic activity of Moringa oleifera Lam: A clinical studyIndian Journal of Pharmacology, 2008
- Female mice are more susceptible to the development of allergic airway inflammation than male miceClinical & Experimental Allergy, 2005