The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
Open Access
- 24 November 2020
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2020, 1-10
- https://doi.org/10.1155/2020/2329196
Abstract
The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population: Purpose. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. Methods. We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. Results. Our study revealed that rs7336610 (OR 1.77, , andFunding Information
- Key Research and Development Projects of Shaanxi Province (2020SF-020, 2018SF-009, 2018JM7027)
This publication has 25 references indexed in Scilit:
- Quantitatively Controlling Expression of miR-17∼92 Determines Colon Tumor Progression in a Mouse Tumor ModelThe American Journal of Pathology, 2014
- MiR-15a, miR-16-1 and miR-17-92 cluster expression are linked to poor prognosis in multiple myelomaLeukemia Research, 2012
- Cancer statistics, 2012CA: A Cancer Journal for Clinicians, 2012
- Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell linesOncogene, 2009
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA ClustersCell, 2008
- The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human PapillomavirusJournal of Dental Research, 2007
- A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell ProliferationCancer Research, 2005
- c-Myc-regulated microRNAs modulate E2F1 expressionNature, 2005
- Habitual Risk Factors for Head and Neck CancerOtolaryngology -- Head and Neck Surgery, 2004
- Identification and Characterization of a Novel Gene, C13orf25 , as a Target for 13q31-q32 Amplification in Malignant LymphomaCancer Research, 2004