Purpose: This study aims to examine the application of scientific approaches in learning in Madrasah Ibtidaiyah, classify the forms of learning activities of learners in Madrasah Ibtidaiyah, and analyze the significant influence between scientific approaches to student learning activities in Madrasah Ibtidaiyah, Indonesia. Approach/Methodology/Design: In this study, a mixed method is employed. The instruments in this study are observation guidelines, interview guidelines, questionnaire guidelines, and document analysis. Data were collected through observation, questionnaires, documentation, and reference tracing. Data processing and analysis techniques are carried out in two ways, namely processing and analyzing data qualitatively and quantitatively, including descriptive analysis, and simple linear regression analysis. Findings: The results of this study show that in general Madrasah Ibtidaiyah teachers have applied a scientific approach in science learning in accordance with the procedures contained in the thematic learning of 2013 curriculum. In terms of students' learning activities, science teachers have improved students' learning activities through visual, oral, listening, writing, drawing, motoric, mental, and emotional activities. The scientific approach employed has positively influenced learning activities with the regression value obtained at 0.436. Practical Implication: The implication of this research is that systemic and systematic measures are needed in developing a scientific approach from the authorities with the provision of adequate facilities in order to implement it more optimally. Employing scientific approaches improve students’ learning process not only in Madrasah, but contributes to the development of scientific thinking can be done by parents in the family environment. Originality/value: This research is useful for teachers in developing pedagogic and professional competencies.