AIM: To study drug-drug interactions in myocardial infarction patients. METHODOLOGY: A prospective interventional study was done on myocardial infarction with drug interactions patients admitted in tertiary government and corporate hospital, Visakhapatnam Andhra Pradesh, India. Information regarding the gender, risk factors, type of drug interactions as major, moderate, minor were recorded in a standard questionnaire (case report form).RESULTS: A total of 100 cases were included after excluding missing data. Out of 100 cases,62 were male and 38 were female.Myocardial infarction in patients in which we assessed risk factors among them were HTN-67%,previous history of CVD-66%,family history-60%,Hyperlipidemia-40%,Diabetes milletus-38%,smoking-64%,Drug interactions were Major,Moderate,Minor.Major interactions were 24, Moderate interactions were 318, Minor interactions were 91.CONCLUSION: Based on the above data risk factors mostly seen in HTN and previous history of CVD, drug interactions mostly observed were moderate drug interactions.