Physical activity and the progression of coronary artery calcification
Open Access
- 20 September 2021
- Vol. 107 (21), 1710-1716
- https://doi.org/10.1136/heartjnl-2021-319346
Abstract
Background The association of physical activity with the development and progression of coronary artery calcium (CAC) scores has not been studied. This study aimed to evaluate the prospective association between physical activity and CAC scores in apparently healthy adults. Methods Prospective cohort study of men and women free of overt cardiovascular disease who underwent comprehensive health screening examinations between 1 March 2011 and 31 December 2017. Baseline physical activity was measured using the International Physical Activity Questionnaire Short Form (IPAQ-SF) and categorised into three groups (inactive, moderately active and health-enhancing physically active (HEPA)). The primary outcome was the difference in the 5-year change in CAC scores by physical activity category at baseline. Results We analysed 25 485 participants with at least two CAC score measurements. The proportions of participants who were inactive, moderately active and HEPA were 46.8%, 38.0% and 15.2%, respectively. The estimated adjusted average baseline CAC scores (95% confidence intervals) in participants who were inactive, moderately active and HEPA were 9.45 (8.76, 10.14), 10.20 (9.40, 11.00) and 12.04 (10.81, 13.26). Compared with participants who were inactive, the estimated adjusted 5-year average increases in CAC in moderately active and HEPA participants were 3.20 (0.72, 5.69) and 8.16 (4.80, 11.53). Higher physical activity was association with faster progression of CAC scores both in participants with CAC=0 at baseline and in those with prevalent CAC. Conclusion We found a positive, graded association between physical activity and the prevalence and the progression of CAC, regardless of baseline CAC scores.Keywords
This publication has 29 references indexed in Scilit:
- Physical activity and the risk of type 2 diabetes: a systematic review and dose–response meta-analysisEuropean Journal of Epidemiology, 2015
- The effect of physical activity or exercise on key biomarkers in atherosclerosis – A systematic reviewAtherosclerosis, 2014
- Plasma–Parathyroid Hormone Is Associated With Subclinical and Clinical Atherosclerotic Disease in 2 Community-Based CohortsArteriosclerosis, Thrombosis, and Vascular Biology, 2014
- Objectively Assessed Physical Activity, Sedentary Time, and Coronary Artery Calcification in Healthy Older AdultsArteriosclerosis, Thrombosis, and Vascular Biology, 2012
- Cardiovascular events with absent or minimal coronary calcification: The Multi-Ethnic Study of Atherosclerosis (MESA)American Heart Journal, 2009
- Diagnostic and Prognostic Value of Absence of Coronary Artery CalcificationJACC: Cardiovascular Imaging, 2009
- Risk Factors for the Progression of Coronary Artery Calcification in Asymptomatic SubjectsJournal of the American College of Cardiology, 2007
- International Physical Activity Questionnaire: 12-Country Reliability and ValidityMedicine & Science in Sports & Exercise, 2003
- Flexible parametric proportional‐hazards and proportional‐odds models for censored survival data, with application to prognostic modelling and estimation of treatment effectsStatistics in Medicine, 2002
- Quantification of coronary artery calcium using ultrafast computed tomographyJournal of Invasive Cardiology, 1990