The interaction of ectoparasite in correlation to its host’s skin is important. The extent of interaction somewhat makes these parasites able to survive in the harsh conditon of the host’s skin. Their existence mostly in the context of gaining their nutrition and perhaps continue its regeneration. Because these diseases caused by ectoparasite are easility transmitted, widespread, and the state of polyparasitism is often took place in a single vulnerable host, and significant primary and secondary morbidity and or complication occurs, which can worsen the course of the inital disease. This minireview aim to discuss about the interlinkage of some EPSD agents in correlation to its host’s skin, their interaction and what makes these endoparasites able to survive in the skin in the context of gaining their nutrition.