The Contribution of Innervation to Tissue Repair and Regeneration
- 6 June 2022
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 14 (9), a041233
- https://doi.org/10.1101/cshperspect.a041233
Abstract
Animals such as amphibians have an incredible capacity for regeneration with some being able to regrow their tail or appendages. Although some mammalian tissues like the skin and bones can repair following injury, there are only a few examples of true multilineage regeneration, including the distal portion of the digit tip. In both amphibians and mammals, however, to achieve successful repair or regeneration, it is now appreciated that intact nerve innervation is a necessity. Here, we review the current state of literature and discuss recent advances that identify axon-derived signals, Schwann cells, and nerve-derived mesenchymal cells as direct and indirect supporters of adult tissue homeostasis and repair. We posit that understanding how nerves positively influence repair and regeneration could lead to targeted regenerative medicine strategies to enhance tissue repair in humans.Keywords
This publication has 91 references indexed in Scilit:
- Sox2-Mediated Regulation of Adult Neural Crest Precursors and Skin RepairStem Cell Reports, 2013
- Agr genes, missing in amniotes, are involved in the body appendages regeneration in frog tadpolesScientific Reports, 2013
- Skin shedding and tissue regeneration in African spiny mice (Acomys)Nature, 2012
- Mouse digit tip regeneration is mediated by fate-restricted progenitor cellsProceedings of the National Academy of Sciences of the United States of America, 2011
- Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insultActa Neuropathologica, 2010
- Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in miceJCI Insight, 2010
- SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem CellsCell Stem Cell, 2009
- Comparative Aspects of Animal RegenerationAnnual Review of Cell and Developmental Biology, 2008
- Role of platelet-derived growth factors in physiology and medicineGenes & Development, 2008
- Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult VertebrateScience, 2007