Corrosive substances ingestion: a review
Open Access
- 14 September 2019
- journal article
- review article
- Published by Taylor & Francis Ltd in Critical Reviews in Toxicology
- Vol. 49 (8), 637-669
- https://doi.org/10.1080/10408444.2019.1707773
Abstract
Corrosive chemical substance ingestions are a major problem, especially in developing countries, but also in developed countries such as the United States, France, and Belgium. Ingestions may be deliberate as suicide attempts (mostly in adolescents and adults) or accidental (mostly in children). The results can be devastating in terms of individual suffering and disability, but also in terms of resource utilization and costs. In developing countries, outcomes may be worse because of limited medical/surgical resources. Common sequelae include gastrointestinal (GI) tract (esophagus, stomach, pylorus, and duodenum) stricture formation, GI tract perforation, and hemorrhage. Systemic effects may also occur, such as disseminated intravascular coagulation (DIC), multi-organ system failure, and sepsis. Various interventions in the acute phase to reduce the severity of injury have been attempted, but there are no large controlled clinical trials to demonstrate efficacy. Dilation therapy in various forms is commonly used for the treatment of strictures and a variety of surgical procedures including esophagectomy and delayed replacement may be required in severe corrosive injury cases.Keywords
This publication has 153 references indexed in Scilit:
- Corrosive oesophageal injuries: a preventable menacePan African Medical Journal, 2013
- Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in childrenWorld Journal of Gastroenterology, 2012
- Corrosive Poisonings in AdultsMateria Socio-Medica, 2012
- The Role of Age in Predicting the Outcome of Caustic Ingestion in Adults: A Retrospective AnalysisBMC Gastroenterology, 2011
- Endoscopic balloon dilation for benign gastric outlet obstruction in adultsWorld Journal of Gastrointestinal Endoscopy, 2010
- Oesophageal corrosive injuries in children: a forgotten social and health challenge in developing countriesBulletin of the World Health Organization, 2009
- Chemical injuries of the oesophagus: aetiopathological issues in NigeriaJournal of Cardiothoracic Surgery, 2009
- Pattern of corrosive ingestion in southwestern Saudi ArabiaSaudi Journal of Gastroenterology, 2009
- Caustic ingestion in adults: The role of endoscopic classification in predicting outcomeBMC Gastroenterology, 2008
- Liquid caustic ingestions: An in vitro study of the effects of buffer, neutralization, and dilutionAnnals of Emergency Medicine, 1985