Metformin Role in Diabetic Patients with Tuberculosis: a Review
Published: 28 June 2021
Journal of Tropical Pharmacy and Chemistry , Volume 5, pp 264-270; https://doi.org/10.25026/jtpc.v5i3.275
Abstract: Tuberculosis (TB) epidemic is a global health challenge, and WHO estimated the incidence of the new cases reaching 11.1 million people in 2017. Indonesia is classified as a high TB burden country, with 8% of its population infected by TB and ranks third in the world. Type-2 diabetes mellitus (T2DM) is known comorbidity for TB patients. TB-T2DM patients have a higher chance of morbidity, mortality, relapse, bacterial resistance, treatment failure, and slower sputum conversion than TB patients without T2DM. Recent studies suggest that metformin may have a potential synergistic role for TB-T2DM patients. Metformin has immunomodulator properties that can improve the body's immune response and inflammatory response against TB in individuals with T2-DM.
Keywords: Diabetic / Metformin / Tuberculosis / treatment / TB T2DM patients / TB patients
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