Climate change poses great risks to poverty alleviation, food security and livelihoods sustainability in sub-Saharan Africa, declining crop yields and livestock productivity, especially in ASALs that suffer from fragile ecosystems characterized by frequent droughts and low rainfall. Climate-Smart Agriculture (CSA) objectives of improving productivity and incomes, adaptation, resilience to climate change and mitigation on GHGs emissions, are responses to these climate risks. CSA technologies, innovation and management practices (TIMPs) in general do exist, however they are concentrated in crop farming neglecting livestock production and especially in marginalized areas such as ASALs, which forms 85% of Kenyan land mass and is dominated by pastoral and nomadic livestock production. Most CSA practices are mainly at the production level and hardly extend to the entire value chain, and diffusion is slow due to several barriers. A mixed method approach was used to evaluate barriers to actors’ adoption of CSA in the pastoral Livestock red meat value chain starting from input suppliers, producers, to consumers (pasture to plate). This study used six broad perspectives to examine the barriers: 1) Knowledge and institutional; 2) Market and financial; 3) Policy and incentives; 4) Networks and engagement platforms; 5) Cultural and social; 6) Physical infrastructure barriers. These barriers can be surmounted with concerted efforts from the government, development partners, pastoral communities, value chain actors and public private partnership among others. Efforts such as modernization of the pastoral red meat value chains, integration of MSMEs into the livestock systems, access to affordable financing, availability of context based, affordable CSA TIMPs, incentives, policies and institutional support, which currently remains inadequate. Institutional barriers like lack of capacity, coupled with knowledge and behavioral barriers hinder adoption. Financial institutions and cooperative societies can be enablers, however, their reluctance to invest in the sector is a barrier too.