Association Between the Cerebral Autoregulation Index (Pressure Reactivity), Patient’s Clinical Outcome, and Quality of ABP(t) and ICP(t) Signals for CA Monitoring
Open Access
- 20 March 2020
- Vol. 56 (3), 143
- https://doi.org/10.3390/medicina56030143
Abstract
Background and Objectives: The aim of this study was to explore the association between the cerebral autoregulation (CA) index, the pressure reactivity index (PRx), the patient’s clinical outcome, and the quality of arterial blood pressure (ABP(t)) and intracranial blood pressure (ICP(t)) signals by comparing two filtering methods to derive the PRx. Materials and Methods: Data from 60 traumatic brain injury (TBI) patients were collected. Moving averaging and FIR (Finite Impulse Response) filtering were performed on the ABP(t) and ICP(t) signals, and the PRx was estimated from both filtered datasets. Sensitivity, specificity, and receiver-operating characteristic (ROC) curves with the area under the curves (AUCs) were determined using patient outcomes as a reference. The outcome chosen for comparison among the two filtering methods were mortality and survival. Results: The FIR filtering approach, compared with clinical outcome, had a sensitivity of 70%, a specificity of 81%, and a level of significance p = 0.001 with an area under the curve (AUC) of 0.78. The moving average filtering method compared with the clinical outcome had a sensitivity of 58%, a specificity of 72%, and a level of significance p = 0.054, with an area under the curve (AUC) of 0.66. Conclusions: The FIR (optimal) filtering approach was found to be more sensitive for discriminating between two clinical outcomes, namely intact (survival) and impaired (death) cerebral autoregulation for TBI treatment decision making.Keywords
This publication has 32 references indexed in Scilit:
- Short pressure reactivity index versus long pressure reactivity index in the management of traumatic brain injuryJournal of Neurosurgery, 2015
- Optimal cerebral perfusion pressure: are we ready for it?Neurological Research, 2013
- Changing patterns in the epidemiology of traumatic brain injuryNature Reviews Neurology, 2013
- Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury*Critical Care Medicine, 2012
- Traumatic brain injury: rethinking ideas and approachesThe Lancet Neurology, 2012
- Critical Thresholds for Cerebrovascular Reactivity After Traumatic Brain InjuryNeurocritical Care, 2011
- Evaluation of the cerebrovascular pressure reactivity index using non-invasive finapres arterial blood pressurePhysiological Measurement, 2010
- 150 Years of Treating Severe Traumatic Brain Injury: A Systematic Review of Progress in MortalityJournal of Neurotrauma, 2010
- A synopsis of brain pressures: which? when? are they all useful?Neurological Research, 2007
- Receiver-Operating Characteristic Analysis for Evaluating Diagnostic Tests and Predictive ModelsJournal of the American College of Cardiology, 2007