A clinical trial of the efficacy of a combination of antiseptic and antimicrobial agent in the treatment of inflammatory processes of the skin and soft tissue
Open Access
- 23 June 2021
- journal article
- Published by QUASAR, LLC in Research and Practical Medicine Journal
- Vol. 8 (2), 51-61
- https://doi.org/10.17709/2410-1893-2021-8-2-5
Abstract
Purpose of the study. To conduct a clinical trial of the local treatment efficacy of skin and soft tissue inflammatory processes combination with sodium carboxymethylcellulose, immobilized miramistin and metronidazole. Patients and methods. The study involved patients with purulent-inflammatory skin processes, divided into two groups – control and experimental – 30 in each. The most common nosological form were abscesses of various localization. In the control group, local treatment was carried out with dioxomethyltetrahydropyrimidine ointment with chloramphenicol, and in the experimental group – with a combination of sodium carboxymethylcellulose with miramistin and metronidazole. We studied the local temperature, wound pH, wound planimetry, the appearance of wounds, the species composition of infectious agents in the discharge from the wound, a general blood test (with the determination of leukocyte indices), blood biochemical parameters, and the number of bed-days in the hospital. The data obtained were processed statistically. Results. The percentage of reduction in the area and volume of wounds in the experimental group was significantly higher than in the control. The maximum rate of wound healing in the experimental group was noted on days 1-3 and amounted to 9.7 (6.3; 15.5) % / day, and in the control group – 5.6 (2.9; 7.7). Starting from the 5th day of treatment, the local temperature indices in the experimental group were significantly lower than in the control group, and the pH values of the wounds in the experimental group tended to neutral values from the 5th day of treatment, and in the control group there was an increase in pH. Most often, S. epidermidis and S. aureus were inoculated from the wound discharge (in total, more than 50 % of observations); in the control group, pathogenic microorganisms were inoculated 1.6 times more often than in the experimental group. Conclusion. Patients in the experimental group were hospitalized for 2.5 days less than patients in the control group. It is possible to recommend further study and application of the combination of miramistin and metronidazole immobilized on the sodium salt of carboxymethylcellulose in the treatment of wounds.Keywords
This publication has 9 references indexed in Scilit:
- Staphylococcal Biofilm Development: Structure, Regulation, and Treatment StrategiesMicrobiology and Molecular Biology Reviews, 2020
- Adaptive expression of biofilm regulators and adhesion factors of Staphylococcus aureus during acute wound infection under the treatment of negative pressure wound therapy in vivoExperimental and Therapeutic Medicine, 2020
- Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteriaProceedings of the National Academy of Sciences of the United States of America, 2020
- In situ Treatment With Novel Microbiocide Inhibits Methicillin Resistant Staphylococcus aureus in a Murine Wound Infection ModelFrontiers in Microbiology, 2020
- Pharmacological control of inflammation in wound healingJournal of Tissue Viability, 2019
- Evaluation of the efficacy of modern wound care dressings in the complex treatment of purulent woundsAmbulatory surgery: hospital-replacing technologies, 2019
- Treatment of severe skin and soft tissue infections: a reviewCurrent Opinion in Infectious Diseases, 2018
- MODERN ASSORTMENT, PROPERTIES AND PERSPECTIVES OF MEDICAL DRESSINGS IMPROVEMENT OF WOUND TREATMENTPharmacy & Pharmacology, 2018
- Эндогенная интоксикация при различных способах лечения распространенных флегмон (доклиническое исследование)Человек и его здоровье, 2017