Treatment optimization of patients with genital endometriosis
Open Access
- 25 May 2021
- journal article
- Published by OU Scientific Route in EUREKA: Health Sciences
- No. 3,p. 3-8
- https://doi.org/10.21303/2504-5679.2021.001682
Abstract
The aim of the research: to optimize the treatment of patients with combined genital pathology, including internal endometriosis (adenomyosis) and inflammatory diseases. Materials and methods: prospective study has been conducted on 160 women with adenomyosis. There were 24 (15 %) patients with the I degree of adenomyosis spreading, 72 (45.0 %) women with the II degree, 33 (20.6 %) patients with the III degree, and 31 (19.4 %) woman with the IV degree of adenomyosis spreading. Microbial flora analysis included bacterioscopic, bacteriological research methods with determination of sensitivity to antibiotics, and PCR method. The concentration of cytokines in the culture medium (supernatant) was determined by the enzyme immunoassay. Results: the obtained data from the study indicate a high percentage of the combination of adenomyosis with chronic inflammatory diseases of the pelvic organs. An immuno-inflammatory reaction preceding adenomyosis is accompanied by the violation of the local cytokine balance. In turn, the increased activity of cytokines and the presence of infectious agents can participate in the relapse of endometriosis. Conclusion: considering the immuno-inflammatory reaction, accompanied by the violation of the local cytokine balance in the development of adenomyosis. The study substantiates the necessity of using antimicrobial therapy in patients with combined genital pathology, including adenomyosis and inflammatory diseasesKeywords
This publication has 18 references indexed in Scilit:
- Increased Risk of Endometriosis in Patients With Lower Genital Tract InfectionMedicine, 2016
- Use of dienogest over 53 weeks for the treatment of endometriosisJournal of Obstetrics and Gynaecology Research, 2015
- Molecular aspects of endometriosisProblemy reproduktsii, 2015
- Pharmacologic therapies in endometriosis: a systematic reviewFertility and Sterility, 2012
- Role of shigella infection in endometriosis: A novel hypothesisMedical Hypotheses, 2008
- Intraperitoneal inflammation decreases endometriosis in a mouse modelHuman Reproduction, 2008
- Inflammatory Status Influences Aromatase and Steroid Receptor Expression in EndometriosisEndocrinology, 2007
- The Pathology of EndometriosisAdvances in Anatomic Pathology, 2007
- Cytokine Production by Immunocompetent Cells of Peritoneal Fluid in Women with External Genital EndometriosisBulletin of Experimental Biology and Medicine, 2004
- Diagnosis and treatment of endometriosisExpert Opinion on Pharmacotherapy, 2003