Quantifying muscle blood flow: a transformative breakthrough in the science of human exercise physiology
Open Access
- 18 November 2022
- journal article
- editorial
- Published by Portland Press Ltd. in Clinical Science
- Vol. 136 (22), 1653-1656
- https://doi.org/10.1042/cs20220101
Abstract
Over 50 years ago, John Wahren and Lennart Jorfeldt published a manuscript in Clinical Science where they detailed a series of studies of leg blood flow during exercise. They used a novel approach to indicator dye dilution: continuous arterial infusions of dye using venous samples. This technique allowed them to describe for the first time the fundamental relationships between large muscle group exercise, muscle blood flow, and pulmonary and muscle oxygen uptake. They also defined mechanical efficiency, a key measurement of muscle function. This paper formed the basis for research into muscle blood flow and exercise in health and disease and continued to be cited by modern research. In this commentary, we describe the innovations they made, the key observations that came out of their results, and the importance of this manuscript to current research.Keywords
This publication has 11 references indexed in Scilit:
- Point: Skeletal muscle mechanical efficiency does increase with ageJournal of Applied Physiology, 2013
- Counterpoint: Skeletal muscle mechanical efficiency does not increase with ageJournal of Applied Physiology, 2013
- Peripheral CirculationComprehensive Physiology, 2012
- Effects of respiratory muscle work on blood flow distribution during exercise in heart failureJournal Of Physiology-London, 2010
- Measuring muscle blood flow: a key link between systemic and regional metabolismCurrent Opinion in Clinical Nutrition and Metabolic Care, 2008
- Maximal perfusion of skeletal muscle in man.Journal Of Physiology-London, 1985
- Comparison of Blood Flow Measured by Plethysmograph and Flowmeter During Steady State Forearm ExerciseJournal of the American College of Cardiology, 1974
- Leg Blood Flow during Exercise in ManClinical Science, 1971
- Measurement of Cardiac Output by Thermodilution with Constant Rate Injection of IndicatorCirculation Research, 1964
- MEASUREMENT OF BLOOD-FLOW THROUGH SKELETAL MUSCLE BY INTRAMUSCULAR INJECTION OF XENON-133The Lancet, 1964