Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment

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Abstract
Cancer-related cognitive impairment (CRCI) is a significant comorbidity for cancer patients and survivors. Physical activity (PA) has been found to be a strong gene modulator that can induce structural and functional changes in the brain. PA and exercise reduce the risk of cancer development and progression and has been shown to help in overcoming post-treatment syndromes. Exercise plays a role in controlling cancer progression through direct effects on cancer metabolism. In this review, we highlight several priorities for improving studies on CRCI in patients and its underlying potential metabolic mechanisms.
Funding Information
  • National Institutes of Health (1U01DK103260, 1R01DK100974, U24 DK097154, NIH NCATS UCLA CTSI UL1TR000124)
  • U.S. Department of Defense (W81XWH-15-1-0415, W81XWH-19-1-0109)
  • Centers for Disease Control and Prevention (1U01DP006079)