Differential Diagnosis of Thyrotoxic Myopathy
Open Access
- 1 January 2017
- journal article
- Published by Scientific Research Publishing, Inc. in Open Journal of Molecular and Integrative Physiology
- Vol. 07 (02), 25-33
- https://doi.org/10.4236/ojmip.2017.72002
Abstract
Along with hereditary myopathies, there are many exogenic (the same a not hereditary) muscle affections due to the pathology of endocrine gland’s functioning. These forms of muscle pathology are called endocrine myopathies. In the cases of thyroid gland hyperfunction (the same a thyrotoxicosis), different regions of neuromuscular system may be involved in the pathological process. Thyrotoxic myopathy (TM) which is a subject of this investigation, occupies one of the first places between thyrotoxic (the same a thyrotoxicosis) neuromuscular affections. Meanwhile, for a long time in literature there was no clarity about the degree of muscle weakness and atrophy to diagnose TM in a patient. It’s because of the fact that the majority of patients complain of increased fatigue and general weakness due to thyrotoxicosis. In present time TM diagnostics is very rare. TM is a phenocopy (the clinical similar) of many neuromuscular diseases. However in literature, the data about peculiarities of clinical picture of TM is almost completely absent, it isn’t known about the frequency of affection of the isolated muscles or muscle groups, the topography of muscle weakness and successive involvement of isolated muscles in the pathological process during different stages of thyrotoxicosis and myopathy. The questions of differential diagnosis with similar neuromuscular disorders are described very poorly. In present article, we accent our attention at the clinical differentiation of the TM with other neuromuscular diseases, namely muscular dystrophy, myasthenia gravis, polymyositis, Addison’s disease, proximal spinal muscular atrophy, steroid myopathy and neurosis. In our opinion, the early diagnosis of TM may help the diagnosis of thyrotoxicosis in patients who have no classical clinical signs of this disease, i.e. in patients with latent thyrotoxicosis.Keywords
This publication has 10 references indexed in Scilit:
- Dysphagia as a manifestation of thyrotoxicosis: report of three cases and literature review.Dysphagia, 2004
- Experimental Thyrotoxic myopathy: Radioautography of protien synthesis in skeletal muscle and motor neurons of spinal cordNeuromuscular Disorders, 1995
- Pathogenesis of Experimental Thyrotoxic MyopathyEuropean Neurology, 1986
- Thyrotoxic myopathy presenting as dysphagiaPublished by Oxford University Press (OUP) ,1980
- Neuromuscular transmission in thyrotoxicosisJournal of the Neurological Sciences, 1979
- Chronic Spinal Muscular Atrophy Simulating Facioscapulohumeral Type and Limb-Girdle Type of Muscular DystrophyEuropean Neurology, 1977
- Acute bulbar muscle dysfunction and hyperthyroidismThe American Journal of Medicine, 1974
- THYROTOXIC MYOPATHYPublished by Elsevier BV ,1974
- Chronic Thyrotoxic Myopathy with Involvement of Respiratory and Bulbar MusclesBMJ, 1967
- TWO CASES OF GRAVES' DISEASE WITH SIGNS OF A PYRAMIDAL LESION. IMPROVEMENT IN NEUROLOGIC SIGNS DURING TREATMENT WITH ANTITHYROID DRUGSJournal of Clinical Endocrinology & Metabolism, 1960