Comparison between a handheld ultrasound device and a traditional ultrasound for performing transcranial sonography in patients with Parkinson's disease
Open Access
- 27 January 2023
- journal article
- research article
- Published by Wiley in Brain and Behavior
- Vol. 13 (2), e2891
- https://doi.org/10.1002/brb3.2891
Abstract
ObjectiveThe aim of this study is to compare a portable ultrasound (US) device and a traditional US for performing transcranial ultrasonography (CCT) in patients with Parkinson's disease (PD). MethodsThis is a cross-sectional, observational, and analytical study. The study recruited a total of 129 individuals from two public hospitals in the city of Rio de Janeiro in a prospective and non-randomized manner between September 2019 and July 2021 as follows: group A with 31 patients with PD, group B with 65 patients with PD, and group C with 64 healthy individuals. Group A was used to collect data to establish the agreement analysis of the TCS measurements between the two devices. Groups B and C provided data for constructing the receiver operating characteristic curve for the handheld US. The subjects underwent the assessment of the transtemporal bone window (TW) quality, the mesencephalon area, the size of the third ventricle, and the substantia nigra (SN) hyperechogenicity area. ResultsThere was a good agreement between the methods regarding the quality of the TW-Kappa concordance coefficient of 100% for the right TW and 83% for the left, the midbrain area-intraclass correlation coefficient (ICC) of 69%, the SN area ICC = 90% for the right SN and 93% for the left and the size of the third ventricle ICC = 96%. The cutoff point for the SN echogenic area in the handheld US was 0.20 cm(2). ConclusionsThe handheld US is a viable imaging method for performing TCS because it shows good agreement with the measurements performed with traditional equipment, and the measurement of SN echogenic area for PD diagnosis presents good sensitivity and specificity.Keywords
This publication has 26 references indexed in Scilit:
- Transcranial sonography in movement disorders: an interesting tool for diagnostic perspectivesNeurological Sciences, 2015
- MDS clinical diagnostic criteria for Parkinson's diseaseMovement Disorders, 2015
- Transcranial Sonography (TCS) of Brain Parenchyma in Movement Disorders: Quality Standards, Diagnostic Applications and Novel TechnologiesUltraschall in der Medizin - European Journal of Ultrasound, 2014
- Microglia activation is related to substantia nigra echogenicityJournal of Neural Transmission, 2010
- Transcranial Sonography—AnatomyInternational review of neurobiology, 2010
- Transcranial sonography in Parkinson’s diseaseAging Health, 2009
- Transcranial sonography in movement disordersThe Lancet Neurology, 2008
- Contemporary ultrasound systems allow high-resolution transcranial imaging of small echogenic deep intracranial structures similarly as MRI: A phantom studyNeuroImage, 2008
- Transcranial brain parenchyma sonography in movement disorders: State of the artJapanese Journal of Clinical Oncology, 2007
- Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonographyNeurology, 1995