Effects of food and grapefruit juice on single-dose pharmacokinetics of blonanserin in healthy Chinese subjects
- 3 October 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Pharmacology
- Vol. 74 (1), 61-67
- https://doi.org/10.1007/s00228-017-2340-1
Abstract
The purpose of this study was to investigate the potential effects of a meal and grapefruit juice on the pharmacokinetics of blonanserin and its metabolite N-desethyl blonanserin in healthy Chinese volunteers.Keywords
Funding Information
- Key Program of Science and Technology of Guangdong Province (2012A080204017)
- Natural Science Foundation of Guangdong Province (2015A030313808)
- Guangzhou Municipal Key Discipline in Medicine for Guangzhou Brain Hospital (GBH2014-QN05)
- Hospital Pharmacy Research Funds of Guangdong (2015A09)
This publication has 18 references indexed in Scilit:
- Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteersCancer Chemotherapy and Pharmacology, 2014
- Population pharmacokinetics of blonanserin in Chinese healthy volunteers and the effect of the food intakeHuman Psychopharmacology: Clinical and Experimental, 2013
- Blonanserin’s interesting food-effect observations: is lymphatic transport involved?European Journal of Clinical Pharmacology, 2011
- Inconsistent Labeling of Food Effect for Oral Agents across Therapeutic Areas: Differences between Oncology and Non-Oncology ProductsClinical Cancer Research, 2010
- Effect of dose timing in relation to food intake on systemic exposure to blonanserinEuropean Journal of Clinical Pharmacology, 2010
- Intestinal Drug Transporter Expression and the Impact of Grapefruit Juice in HumansClinical Pharmacology & Therapeutics, 2007
- Grapefruit‐Drug Interactions: Can Interactions With Drugs Be Avoided?The Journal of Clinical Pharmacology, 2006
- Two Major Grapefruit Juice Components Differ in Time to Onset of Intestinal CYP3A4 InhibitionThe Journal of pharmacology and experimental therapeutics, 2004
- Drug Interactions with Grapefruit JuiceDrug Safety, 1998
- Drug Interactions with Grapefruit JuiceClinical Pharmacokinetics, 1997