An important direction in the development of regional policy is the realization of the active role of regions as subjects of transition to sustainable development of society. Scientific support of regional management requires additional social and ecological-economic system researches taking into account indicators and factors of sustainable development. On the way to the implementation of the concept of sustainable development of the regions, the main problem is the need to develop an effective system for assessing the progress made in this direction with the help of qualitative and quantitative indicators. After all, these indicators should cover three important components of sustainable development of the regions, provide reliable information for further evaluation and forecasting, be understandable to all stakeholders. Today, there is no single approach to determining both the number of indicators to effectively assess the sustainability of regional development and the issues they should cover. Without effective indicators of sustainable development it is impossible to ensure high quality and efficiency of the management decision-making process in all spheres of society. The article identifies and substantiates a set of environmental indicators and indicators that are used to develop projects for the development of settlements and regions. The authors identify the main problems associated with the assessment of sustainable development in the regions and outline the prospects for further research in this area. A brief analysis of indicator systems for forecasting the state of the environment on the example of the settlement of Velyka Snitynka is given. The following research methods are used in the work: theoretical (study and analysis of scientific literature in the fields of ecology, philosophy, pedagogy, methodology; statistical (descriptive and mathematical); sociological; field, expeditionary (population survey, observation and analysis of socio-ecological factors in the village of Velyka Snitinka). The analysis of the main ecological problems of the studied village is made and the main sources of pollution are defined. Indicators and approaches to forecasting the main indicators of the region's development with the use of statistical data are presented, on the basis of which priority tasks and priority measures are developed.