Serum Lipid Variation in Patients with Dengue Virus Infection and Associated Risks of Cardio Vascular Disorder

Abstract

Background: Dengue virus (DENV) is a most prevalent arbovirus with about 100 million infections worldwide every year. It is endemic in the subtropical and tropical areas in the world, an emerging public health threat. Serum lipidome is a key player in the immune system response of the patient for the period of dengue fever. This study was aimed to assess the lipids deviations in serum of patients with dengue fever. Materials and Methods: Three For this case-control study blood samples of N=65 dengue patients of age ≥18 year were collected from the Mayo Hospital, Lahore. Whereas samples of 45 healthy individuals were collected from the University of the Punjab, Lahore. Blood samples from subjects were collected to analyze serum lipidome. Results: Significantly (P < 0.001) increased serum triglyceride, total cholesterol, low density lipoprotein, and very low-density lipoprotein while a significant (P < 0.001) reduction in high density lipoprotein was observed in the dengue patient’s serum in contrast to the control. Conclusion: We can conclude that DENV infection can contribute to dyslipidemia with subsequent cardiovascular disorder symptoms. Therefore, patients infected with DENV should monitor their serum lipid profiles to deal with DENV induced effects to the cardiovascular physiology.