Background: PPI3K/pAKT/pMTOR expression is important in NHL patients. The cascade of biomarker signals regulates translational events, cell survival, cytoskeleton organisation, and ion transport. pPI3K/pAKT/pMTOR enhance gene transcription increasing lactate dehydrogenase (LDH). LDH is one of the important markers in plasma people with non-Hodgkin’s lymphoma (NHL).Objective: This study aims to determine the correlation between the expression of kPI3K, pAKT, and pMTOR and serum LDH levels in NHL patients.Methods: This study was used an observational approach with a cross-sectional design. The expression score of pPI3K, pAKT, and pMTOR was obtained from medical records and expressed in histoscore obtained from multiplication between intensity (1=weak, 2=medium, 3=strong) with an express area (1=80%). The correlation between the histoscore of pPI3K, pAKT, and pMTOR expressions with LDH levels was statistically analysed using Pearson correlation tests. Results: The mean of pPI3K, pAKT, and pMTOR expression respectively were 5.29 + 2.95; 4.71 + 2.26 and 7.62 + 1.86. There was a weak correlation between pPI3K expression and serum LDH levels in NHL patients (r=0.293). A very weak correlation occurred between pAKT (r=-0.064) and pMTOR (r=-0.172) with serum LDH in NHL patients.Conclusion: There is a weak correlation between pPI3K expression and serum LDH levels in NHL patients. There is a very weak correlation between pAKT and pMTOR with serum LDH in NHL patients.