Acute Lymphoblastic Leukemia with Posterior Reversible Encephalopathy Syndrome in Children: A Report of 2 Cases and Liter-Ature Review
Abstract: 目的：提高对儿童急性淋巴细胞白血病合并可逆性后部脑病综合征的认识。方法：回顾分析南方医院收治的2名急性淋巴细胞白血病合并可逆性后部脑病综合征的临床资料，并结合文献进行分析。结果：2名患儿在急性淋巴细胞白血病治疗过程中出现意识障碍、高血压、抽搐等症状。头颅MRI显示双侧顶、枕、颞叶皮层或皮层下长T2信号。经过降压等对症处理后症状缓解。结论：PRES发病机制是多方面的，早期诊断、早期治疗可使病情在短期内逆转。 Objective: To improve recognition of acute lymphoblastic leukemia with posterior reversible en-cephalopathy syndrome in children. Method: Two ALL children with PRES admitted to Nanfang Hospital were included. Clinical data were retrospectively studied and related literatures were re-viewed. Result: During the treatment of acute lymphoblastic leukemia, 2 children developed symptoms of consciousness disorder, hypertension and convulsion. Cranial MRI showed bilateral parietal, temporal and occipital cortical or subcortical lesions with hypointensity on T2-weighted imaging. Clinical symptoms were resolved soon after supportive care such as anti-hypertension. Conclusion: The pathogenesis of PRES is multifaceted. Early diagnosis and treatment are very im-portant.
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