Signal Transduction Pathways of Neuropilin and Its Ligands

Abstract

神经毡蛋白(Neuropilin, NPN/NRP)是分泌糖蛋白的细胞表面受体，为非酪氨酸激酶受体，有NPN1及NPN2两种亚型。NRPs最初分别通过介导3类信号素和血管内皮生长因子驱动的信号通路参与神经元引导、血管生成和胚胎血管生成的过程。除此之外，NPN目前已知的调节众多信号通路的配体还包括表皮生长因子(Epidermal growth factor, EGF)，成纤维细胞生长因子(Fibroblast Growth Factors, FGF)，血小板衍生生长因子(platelet-derived growth factor, PDGF)和转化生长因子-β (transforming growth factor-β, TGF-β)等。本文总结了NPN的相关配体，并对其信号传导通路作简单介绍，为NPN的研究提供新的思路。 Neuropilin, NPN/NRP is a cell surface receptor that secretes glycoproteins and is a non-tyrosine kinase receptor. There are two subtypes of NPN1 and NPN2. NRPs initially participate in the process of neuron guidance, angiogenesis and embryonic angiogenesis by mediating three types of signal elements and vascular endothelial growth factor-driven signal pathways, respectively. In addition, the known ligands of NPN to regulate many signaling pathways include epidermal growth factor (EGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β). In this paper, the related ligands of NPN are summarized, and their signal transduction pathways are briefly introduced, which provides a new idea for the study of NPN.