Background: Petrol, xylene, and thinner are volatile organic compounds (VOCs), a major class of pollutants that affect the chemistry of the atmosphere and animals including man. The principal mode of contamination is via inhalation. This study aims to elucidate the effects of these compounds on bio-chemical functions in the body of the mouse, Mus musculus Methods: One hundred and twenty adult albino Mus musculus species were randomly assigned to groups (A1, A2, B1, B2, C1, C2, and D1) based on their weights (8-13g for juveniles and 15 – 21g for adults) with specific treatments. The control treatment, A1, was housed in a plastic experimental house free from the test chemical vapor while groups A2 and B1; B2 and C1; C2 and D1 were exposed to pet-rol, thinner, and xylene respectively in wooden exposure chambers for six hours daily for sixty days. Levels of oxidative stress markers (GSH, SOD, CAT, and MDA) were determined using the spectrophotometry. Results: A significant decrease in the values of GSH, activities of SOD and CAT, were observed when compared to the mice in the control experiment as daily exposure to the selected vapor increased. On the other hand, MDA levels increased significantly with increasing daily exposure to vapor from the test chemicals, when compared to the control rats. Conclusion: Based on the findings from this study, the decrease in the SOD, CAT and GSH levels are indications of toxic build up in the blood implying that exposures to these VOCs inhibit natural processes. Thus, VOCs are detrimental to human health and long-term exposure to these organic com-pounds could result in deleterious sub-lethal effects, especially to individual exposed occupationally to them