The paper highlights and analyzes the world and domestic experience in the implementation of cultural and educational museum projects in the modern cultural space of tourist destinations. The introduction of cultural and educational projects based on museum activities contributes to the profits of museums and meet the needs of society in the pursuit of knowledge. Also, the cultural and educational project improves the basic functions of museums (educational and upbringing), strengthens the resonance through the mass promotion of museum activities. Common cultural museum projects include scientific and educational museum conferences, International Museum Day, Museum Night, thematic intercultural festivals, biennials, etc. It has been proved that in recent decades various cultural museum projects have become widespread, which radically change the cultural space of a tourist destination. An example is a successful project of placing museums in abandoned industrial buildings, which gives impetus to the development not only of the museum, but also the area itself, sometimes depressed. The article considers examples of such projects in the world and Ukraine. For many museum institutions, the COVID-19 pandemic and its implications for the cultural sphere as a whole is a challenge that needs to be used to rethink its activities, to introduce new methods of communication with potential museum visitors.