Lessons on skeletal cell plasticity from studying jawbone regeneration in zebrafish
- 16 November 2016
- journal article
- review article
- Published by Portico in BoneKEy Reports
- Vol. 5, 853
- https://doi.org/10.1038/bonekey.2016.81
Abstract
Three major mesenchymal cell types have important roles in determining the shapes of vertebrate animals: bone-producing osteoblasts, cartilage-producing chondrocytes, and fat-producing adipocytes. Although often considered discrete cell types, accumulating evidence is revealing mesenchymal cells of intermediate identities and interconversion of cell types. Such plasticity is particularly evident during adult skeletal repair. In this Review, we highlight recent work in zebrafish showing a role for hybrid cartilage-bone cells in large-scale regeneration of the adult jawbone, as well as their origins in the periosteum. An emerging theme is that the unique mechanical and signaling environment of the adult wound causes skeletal cell differentiation to diverge from the discrete lineages seen during development, which may aid in rapid and extensive regeneration of bone.Keywords
This publication has 67 references indexed in Scilit:
- New tools for studying osteoarthritis genetics in zebrafishOsteoarthritis and Cartilage, 2013
- Regeneration of Amputated Zebrafish Fin Rays from De Novo OsteoblastsDevelopmental Cell, 2012
- Association of cartilage‐specific deletion of peroxisome proliferator–activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine modelArthritis & Rheumatism, 2011
- Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish FinDevelopmental Cell, 2011
- Transient Regenerative Potential of the Neonatal Mouse HeartScience, 2011
- Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood VesselsDevelopmental Cell, 2010
- Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repairBone, 2010
- Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferationNature, 2010
- Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytesNature, 2010
- Mesenchymal Stem Cells: Revisiting History, Concepts, and AssaysCell Stem Cell, 2008