miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease
Open Access
- 17 January 2020
- journal article
- research article
- Published by Elsevier BV in Molecular Therapy Nucleic Acids
- Vol. 19, 1219-1236
- https://doi.org/10.1016/j.omtn.2020.01.010
Abstract
No abstract availableKeywords
Funding Information
- European Regional Development Fund
- Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BrainHealth 2020)
- COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation
- FCT (POCI-01-0145-FEDER-007440, UID/NEU/04539/2013)
- FCT Investigator Programme (IF/00694/2013)
- Marie Curie Carrier Integration Grant (PCIG13-GA-2013-618525)
- HEALTHYAGING 2020 (CENTRO-01-0145-FEDER-000012)
- Bial Foundation (264/16)
- FCT (PTDC/BIM-MEC/0651/2012, SFRH/BPD/120611/2016, SFRH/BPD/108312/2015)
This publication has 69 references indexed in Scilit:
- Alteration of the micro RNA network during the progression of Alzheimer's diseaseEMBO Molecular Medicine, 2013
- The novel object recognition memory: neurobiology, test procedure, and its modificationsCognitive Processing, 2011
- Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related DeficitsCell, 2011
- Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAsNature Structural & Molecular Biology, 2011
- Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matterActa Neuropathologica, 2010
- Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3′UTRsProceedings of the National Academy of Sciences of the United States of America, 2010
- Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIPCell, 2010
- Argonaute HITS-CLIP decodes microRNA–mRNA interaction mapsNature, 2009
- Alterations of the microRNA network cause neurodegenerative diseaseTrends in Neurosciences, 2009
- Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expressionProceedings of the National Academy of Sciences of the United States of America, 2008