Background: Single nucleotide polymorphisms (SNPs) of the IL-28B gene are reliable predictors of chronic HCV disease course after treatment with Peg-IFN and Ribavirin (RBV). Aims, Subjects and Methods: Impacts of IL-28B-SNPs on the response to direct acting antivirals (DAAs) were evaluated in posttreatment negative serum and cellular HCV-PCR (group I), solitary intra-PBMCs viral infections (group II), and positive HCV-RNA serology (group III). Twelve weeks after completing DAAs-therapy, 45 patients were recruited and divided into three groups (n=15each), as afro-mentioned. IL-28B gene sequencing was done to detect SNPs in relation to hepatic parenchymal changes in the selected study populations. Results and conclusion: Changes in liver parenchyma of group III (46.7%) and II (26.6%) were associated with higher HCV-relapse compared to I (P