Synthesis and antimicrobial activities of some novel bis-pyrazole derivatives containing a hydrophosphoryl unit
Open Access
- 31 March 2011
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 2 (1), 25-35
- https://doi.org/10.5155/eurjchem.2.1.25-35.208
Abstract
Vilsmeier-Haack reaction conditions were applied on some methyl ketone aryl phosphonicdihydrazones to yield some interesting bis-pyrazole derivatives containing a hydro-phosphoryl unit. Bis-{4-formyl-3-aryl-1H-pyrazol-1-yl}phosphine oxides (4a,b) were condensed with some nucleophiles such as aniline, phenacyltriphenylphosphonium bromide and 4-phenylthiosemicarbazide followed by treatment with thioglycolic acid, diethyl phosphite and/or acetic anhydride to yield a novel class of bis-pyrazoles containing sulfur and phosphorus derivatives. Most of the newly synthesized compounds were evaluated for their in vitro antimicrobial activities.Keywords
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