Immune Function of the Liver

Abstract

人体肝脏具有多种免疫学功能。它独特的解剖学特点以及肝脏内多种参与免疫反应的细胞使它成为人体免疫系统的哨兵。了解肝脏发挥免疫功能的分子机制对于肝脏相关疾病发病机制的阐释及寻找有效的药物治疗靶点都有十分重要的意义。本文综述了肝脏的解剖学结构以及肝细胞、Kupffer细胞、肝血窦内皮细胞、树突状细胞、肝星状细胞以及胆管细胞通过表达特定分子来介导免疫反应的过程。 Human liver possesses many immunological functions. Its unique anatomical characteristics and multiple cells within liver which were involved in immunoreaction make it the sentinel of the human immune system. Understanding the molecular mechanism of liver immune function is of great significance to elucidate the pathogenesis of liver-related diseases and to find effective drug treatment targets. Here, we review the anatomy of the liver and the immunoreaction processes of multiple cells within liver through expressing specific molecules.