Uric Acid as a Predictor for Early Allograft Dysfunction after Living Donor Liver Transplantation: A Prospective Observational Study
Open Access
- 21 June 2021
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 10 (12), 2729
- https://doi.org/10.3390/jcm10122729
Abstract
Early allograft dysfunction (EAD) is a postoperative complication that may cause graft failure and mortality after liver transplantation. The objective of this study was to examine whether the preoperative serum uric acid (SUA) level may predict EAD. We performed a prospective observational study, including 61 donor/recipient pairs who underwent living donor liver transplantation (LDLT). In the univariate and multivariate analysis, SUA ≤4.4 mg/dL was related to a five-fold (odds ratio (OR): 5.16, 95% confidence interval (CI): 1.41–18.83; OR: 5.39, 95% CI: 1.29–22.49, respectively) increased risk for EAD. A lower preoperative SUA was related to a higher incidence of and risk for EAD. Our study provides a new predictor for evaluating EAD and may exert a protective effect against EAD development.Funding Information
- Chang Gung Memorial Hospital (CMRPG3H1191-3, CMRPG3K1881)
This publication has 30 references indexed in Scilit:
- Regulation of uric acid metabolism and excretionInternational Journal of Cardiology, 2015
- Immediate Postoperative Low Platelet Counts After Living Donor Liver Transplantation Predict Early Allograft DysfunctionMedicine, 2015
- Roles of diets and dietary factors in the pathogenesis, management and prevention of abnormal serum uric acid levelsPharmaNutrition, 2015
- Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trialThe Lancet Neurology, 2014
- Early allograft dysfunction: Causes, recognition, and managementLiver Transplantation, 2013
- High plasma uric acid concentration: causes and consequencesDiabetology & Metabolic Syndrome, 2012
- Is there anything good in uric acid?QJM: An International Journal of Medicine, 2011
- Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factorsLiver Transplantation, 2010
- Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humansAtherosclerosis, 2009