COVID-19 should not target children in the first place, but they are at great risk of being among the biggest casualties of the pandemic. While the direct health effects of COVID-19 have luckily not affected them-at least until now-the crisis has a profound impact on their well-being. In particular, all children, of all ages and in all countries, are impacted by socio-economic impacts and, in some cases, by mitigation measures which, on the other hand, may do more harm than good. This is a universal epidemic, and the effect will last forever for certain children. In addition, there would be no fair distribution of the negative effects of this pandemic. Children in the poorest countries and those already in deprived or vulnerable circumstances are supposed to be the most detrimental to them. This is an unprecedented epidemic and poses unprecedented threats to children's rights, protection and growth around the world. Only unparalleled international solidarity with children and humanity can reduce these threats.