In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15
Open Access
- 27 July 2020
- journal article
- letter
- Published by Springer Science and Business Media LLC in Signal Transduction and Targeted Therapy
- Vol. 5 (1), 1-3
- https://doi.org/10.1038/s41392-020-00245-0
Abstract
No abstract availableKeywords
Funding Information
- National Natural Science Foundation of China (81673304, 81973160, 81830083)
This publication has 5 references indexed in Scilit:
- PROTACs: great opportunities for academia and industrySignal Transduction and Targeted Therapy, 2019
- Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820Structure, 2019
- Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16Nature Chemical Biology, 2019
- Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7Journal of Medicinal Chemistry, 2018
- Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15Science, 2017