Abstract: Monkeypox is a rare zoonotic disease that is caused by the monkeypox virus, a member of the Poxviridae family. Avoid close contact with animals, whether they are living or dead, especially in endemic areas where this could be a source of infection transmission to healthy people. Separate sick people from those who might be contaminated. Frontline medical staff should be instructed and trained to rigorously adhere to traditional safety practices when dealing with verified or suspected cases. At the nation's entry and exit points, vaccination booths should be placed in order to stop the global spread of this contagious disease. Through extensive public awareness initiatives, people should be informed about sickness prevention, risk factors, and treatments. The public health departments of every nation should be alert for any signs that someone may be suffering from an unusual rash.