Association of Vitamin D Receptor Polymorphisms to Pulmonary Tuberculosis in Turkish Patients: An Up-to-date Meta-Analysis and A Case-Control Study
- 30 September 2021
- journal article
- research article
- Published by Bilimsel Tip Publishing House in Flora the Journal of Infectious Diseases and Clinical Microbiology
- Vol. 26 (3), 477-487
- https://doi.org/10.5578/flora.20219716
Abstract
Introduction: Tuberculosis is a major global health issue, threatening millions of lives every year. To understand the interactions between host and the pathogenic factors, many association studies are being held in different populations and most of the time results are controversial. Vitamin D receptor is one of the immunomodulatory molecules that may have an effect on susceptibility to tuber-culosis. Up to now, there was no positive association reported with the tuberculosis and Fok I or Taq I polymorphisms of VDR gene in tuberculosis patients of Turkish origin. The aim of this study was to make an updated meta-analysis and a case-control study in our group of patients for figuring out the association between Fok I and Taq I polymorphisms of VDR and TB. Materials and Methods: In the present study, association of pulmonary tuberculosis and VDR gene's Fok I (rs 2228570) and Taq I (rs20731236) polymorphisms were investigated in our patient group from Malatya, and a comparison was made by a meta-analysis with the mentioned polymorphisms. Ninety-four healthy controls and 80 patients are subjects of case control study. The samples are genotyped for Taq I and Fok I polymorphisms by using TaqMan SNP genotyping kits. The allelic and genotypic distributions were analyzed by exact significance of the Pearson's test or Fisher's exact tests. Meta-analyses for each SNP were conducted under four different genetic models. The statistical significance of the pooled ORs was determined by a Z test and publication bias was evaluated by Egger's test. Results: Our case control study Taq I polymorphism showed no significant association to TB which also matched with our meta-analysis. On the other hand, for Fok I polymorphism, genotypes and allele frequencies were significantly different in our focus group (p 0.044). Sex based analysis gave significantly different results in women with TB as well even though our meta-analysis showed no association to that polymorphism. Conclusion: The reasons underlying the susceptibility to TB is still not clear. The immune response process is so complex and many molecules are taking part in these reactions. So, there are a lot of candidate molecules to be checked in the association studies. VDR is still one of those molecules and may be other than by checking single SNPs, haplotypes could be under investigation with bigger populations.Keywords
This publication has 19 references indexed in Scilit:
- VDR and VDBP genes polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese populationJournal of Microbiology, Immunology and Infection, 2016
- The NRAMP1, VDR, TNF-α, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case–control studyInfection, Genetics and Evolution, 2016
- An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese populationInternational Journal of Infectious Diseases, 2015
- Association between vitamin D receptor polymorphisms and haplotypes with pulmonary tuberculosisBiomedical Reports, 2014
- Vitamin D Receptor GeneTaqI,BsmI andFokI Polymorphisms in Korean Patients with TuberculosisImmune Network, 2011
- The association between BsmI variant of vitamin D receptor gene and susceptibility to tuberculosisMolecular Biology Reports, 2010
- Vitamin D receptor homozygote mutant tt and bb are associated with susceptibility to pulmonary tuberculosis in the Iranian populationInternational Journal of Infectious Diseases, 2010
- Vitamin D and tuberculosisNutrition Reviews, 2009
- DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West AfricansGenes & Immunity, 2007
- Association of HLA-DR, -DQ, and Vitamin D Receptor Alleles and Haplotypes with Tuberculosis in the Venda of South AfricaHuman Immunology, 2006