Structural Aspects of Auxin Signaling
- 17 May 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 14 (1), a039883
- https://doi.org/10.1101/cshperspect.a039883
Abstract
Auxin signaling regulates growth and developmental processes in plants. The core of nuclear auxin signaling relies on just three components: TIR1/AFBs, Aux/IAAs, and ARFs. Each component is itself made up of several domains, all of which contribute to the regulation of auxin signaling. Studies of the structural aspects of these three core signaling components have deepened our understanding of auxin signaling dynamics and regulation. In addition to the structured domains of these components, intrinsically disordered regions within the proteins also impact auxin signaling outcomes. New research is beginning to uncover the role intrinsic disorder plays in auxin-regulated degradation and subcellular localization. Structured and intrinsically disordered domains affect auxin perception, protein degradation dynamics, and DNA binding. Taken together, subtle differences within the domains and motifs of each class of auxin signaling component affect signaling outcomes and specificity.This publication has 96 references indexed in Scilit:
- Mutations in the TIR1 Auxin Receptor That Increase Affinity for Auxin/Indole-3-Acetic Acid Proteins Result in Auxin HypersensitivityPlant Physiology, 2013
- Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cellsProceedings of the National Academy of Sciences of the United States of America, 2012
- A Synthetic Approach Reveals Extensive Tunability of Auxin SignalingPlant Physiology, 2012
- A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxinNature Chemical Biology, 2012
- Auxin-inducible protein depletion system in fission yeastBMC Cell Biology, 2011
- The auxin signalling network translates dynamic input into robust patterning at the shoot apexMolecular Systems Biology, 2011
- Complex regulation of the TIR1/AFB family of auxin receptorsProceedings of the National Academy of Sciences of the United States of America, 2009
- The Biology of Chromatin Remodeling ComplexesAnnual Review of Biochemistry, 2009
- Convergence of Signaling Pathways in the Control of Differential Cell Growth in ArabidopsisDevelopmental Cell, 2004
- Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1Nature, 1993