Photo-Promoted Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CN for the Synthesis of β,γ-Unsaturated Nitriles
- 7 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 23 (18), 7188-7193
- https://doi.org/10.1021/acs.orglett.1c02585
Abstract
An efficient, catalyst/photocatalyst-free, and cost-effective methodology for the decarboxylative alkylation of α,β-unsaturated carboxylic acids to synthesize β,γ-unsaturated nitriles has been developed. The reaction proceeded in an environmentally benign atmosphere of blue light-emitting diode irradiation with K2CO3 and water at room temperature. The methodology worked for a wide range of substrates (22 examples) with up to 83% yield. The protocol is also compatible for gram-scale synthesis.Keywords
Funding Information
- National Natural Science Foundation of China (21961045, 22061048)
- Yunnan Provincial Engineering Research Center Construction Plan Funding of Universities
- Yunnan Provincial Key Laboratory Construction Plan Funding of Universities
- Yunnan Province (202005AC160016)
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