A novel methacrylate derivative polymer that resists bacterial cell‐mediated biodegradation
- 2 December 2021
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Vol. 110 (5), 991-1000
- https://doi.org/10.1002/jbm.b.34972
Abstract
This study tests biodegradation resistance of a custom synthesized novel ethylene glycol ethyl methacrylate (EGEMA) with ester bond linkages that are external to the central polymer backbone when polymerized. Ethylene glycol dimethacrylate (EGDMA) with internal ester bond linkages and EGEMA discs were prepared in a polytetrafluoroethylene (PTFE) mold using 40 μl macromer and photo/co-initiator mixture cured for 40 s at 1000 mW/cm2. The discs were stored in the constant presence of Streptococcus mutans (S. mutans) in Todd Hewitt Yeast + Glucose (THYE+G) media up to 9 weeks (n = 8 for each macromer type) and physical/mechanical properties were assessed. Initial measurements EGEMA versus EGDMA polymer discs showed equivalent degree of conversion (45.69% ± 2.38 vs. 46.79% ± 4.64), diametral tensile stress (DTS; 8.12± 2.92 MPa vs. 6.02 ± 1.48 MPa), and low subsurface optical defects (0.41% ± 0.254% vs. 0.11% ± 0.074%). The initial surface wettability (contact angle) was slightly higher (p ≤ .012) for EGEMA (62.02° ± 3.56) than EGDMA (53.86° ± 5.61°). EGDMA showed higher initial Vicker's hardness than EGEMA (8.03 ± 0.88 HV vs. 5.93 ± 0.69 HV; p ≤ .001). After 9 weeks of S. mutans exposure, EGEMA (ΔDTS—1.30 MPa) showed higher resistance to biodegradation effects with a superior DTS than EGDMA (ΔDTS—6.39 MPa) (p = .0039). Visible and scanning electron microscopy images of EGEMA show less surface cracking and defects than EGDMA. EGDMA had higher loss of material (18.9% vs. 8.5%, p = .0009), relative changes to fracture toughness (92.5% vs. 49.2%, p = .0022) and increased water sorption (6.1% vs. 1.9%, p = .0022) compared to EGEMA discs. The flipped external ester group linkage design is attributed to EGEMA showing higher resistance to bacterial degradation effects than an internal ester group linkage design methacrylate.Keywords
Funding Information
- National Institute of Dental and Craniofacial Research (5R44DE024013)
- University of Minnesota
- Dental Research Center
- National Institutes of Health (5R44DE024013)
This publication has 47 references indexed in Scilit:
- Resin composite restorative materialsAustralian Dental Journal, 2011
- Biodegradation of Resin-Dentin Interfaces Increases Bacterial MicroleakageJournal of Dental Research, 2010
- In vitro stability of methylmethacrylic acid, TEGDMA and HEMA exposed to esterasesDental Materials, 2009
- Correlation between Thermal and Mechanical Properties of the 10NiCr11Journal of ASTM International, 2009
- Preparation and Evaluation of Dental Resin Luting Agents with Increasing Content of Bisphenol-A Ethoxylated DimethacrylateJournal of Biomaterials Applications, 2008
- Catalysts for Suzuki−Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand StructureJournal of the American Chemical Society, 2005
- Mechanisms of buccal mucoadhesion of novel copolymers of acrylic acid and polyethylene glycol monomethylether monomethacrylateJournal of Controlled Release, 1997
- Photopolymerized multifunctional (meth)acrylates as model polymers for dental applicationsBiomaterials, 1996
- Palladium-Catalyzed Cross-Coupling Reactions of Organoboron CompoundsChemical Reviews, 1995
- A new preparation of highly functionaized aromatic and heteroaromatic zinc and copper organometallicsTetrahedron Letters, 1990