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Patchouli alcohol isolated from Pogostemon cablin mediates endothelium-independent vasorelaxation by blockade of Ca 2+ channels in rat isolated thoracic aorta

Published: 1 June 2018

Abstract: PA may act as a Ca antagonist to exert an intensively vasorelaxant effects through endothelium-independent pathway, and its mechanisms underlying the vasoactivities seem to be associated with the blockade of extracellular Ca influx through VDCCs and ROCCs in vascular smooth muscle cells (VSMCs) membrane and intracellular Ca releases through IPR- and RYR-mediated Ca channels in sarcolemma.
Keywords: And endothelium-independence / Ca(2+) channels / Patchouli alcohol / Thoracic aorta / Vasorelaxation

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