Phenotyping respiratory decompensation following definitive closure of the patent ductus arteriosus in preterm infants
- 14 October 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Perinatology
- Vol. 42 (5), 649-654
- https://doi.org/10.1038/s41372-021-01226-z
Abstract
Objective To identify risk factors associated with high-frequency ventilation (HFV) following definitive closure of the patent ductus arteriosus (PDA). Methods We performed a retrospective study of premature infants (<37 weeks) who were mechanically ventilated before and after surgical or transcatheter PDA closure. Primary outcome was HFV requirement within 24 h of procedure. Logistic regression was used to estimate clinical associations with post procedure HFV requirement. Results We identified 110 infants who were mechanically ventilated before PDA closure, of which 48 (44%) escalated to HFV within 24 h after closure. In the multivariable model, surgical ligation (OR 21.5, 95% CI 1.6–284), elevated Respiratory Severity Score (RSS) 1 h post-procedure (OR 1.78, 95% CI 1.07–2.99) and 12 h post-procedure (OR 2.12, 95% CI 1.37–3.26) were independent predictors of HFV. Conclusion Surgical ligation and elevated RSS values over the first 12 h after PDA closure are risk factors for HFV.Keywords
This publication has 48 references indexed in Scilit:
- Non‐invasively derived respiratory severity score and oxygenation index in ventilated newborn infantsPediatric Pulmonology, 2013
- Use of Targeted Neonatal Echocardiography to Prevent Postoperative Cardiorespiratory Instability after Patent Ductus Arteriosus LigationThe Journal of Pediatrics, 2012
- Patent ductus arteriosus ligation is associated with impaired left ventricular systolic performance in premature infants weighing less than 1000 gThe Journal of Thoracic and Cardiovascular Surgery, 2010
- Occurrence of bloodstream infection with different types of central vascular catheter in critically neonatesJournal of Infection, 2010
- Short-Term Outcomes of Patent Ductus Arteriosus Ligation in Preterm Neonates: Reason for Concern?American Journal of Perinatology, 2009
- Patent ductus arteriosus ligation in neonates: preoperative predictors of poor postoperative outcomesJournal of Pediatric Surgery, 2008
- Acute Hemodynamic Decompensation Following Patent Ductus Arteriosus Ligation in Premature InfantsJournal of Investigative Surgery, 2008
- Changes in Myocardial Function and Hemodynamics after Ligation of the Ductus Arteriosus in Preterm InfantsThe Journal of Pediatrics, 2007
- Risk Factors Predicting Vasopressor Use After Patent Ductus Arteriosus LigationAmerican Journal of Perinatology, 2003
- Response to high frequency jet ventilation may predict the need for extracorporeal membrane oxygenationEuropean Respiratory Journal, 1996