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Reversing endothelial dysfunction with empagliflozin to improve cardiomyocyte function in cardiorenal syndrome

, Stéphane Burtey
Published: 1 May 2021
Kidney International , Volume 99, pp 1062-1064; doi:10.1016/j.kint.2021.01.008

Abstract: Sodium-glucose cotransporter 2 inhibitors offer cardiovascular and renal benefits in patients with chronic kidney disease through not yet clearly defined mechanisms. Juni et al. showed that sodium-glucose cotransporter 2 inhibitor empagliflozin exposure in vitro can restore cardiomyocyte function by counteracting harmful effects of uremic serum on the endothelium-cardiomyocyte crosstalk between endothelial cells and cardiomyocytes. The author's findings improved our understanding of cardiovascular impairment in chronic kidney disease and provided new perspectives for the beneficial effects of sodium-glucose cotransporter 2 inhibitor therapy.
Keywords: chronic kidney disease / cardiomyocyte / endothelial / function / cardiovascular / sodium glucose cotransporter

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