Introduction: In teeth with incomplete rhizogenesis, the canal is frustoconical and broad, and the foramen is absent. The disinfection and obturation protocol must be adapted to keep the treatment within the root limits. Mineral Trioxide Aggregate (MTA) performs an apexification by creating a hard tissue barrier with cement deposits, it is not toxic to periradicular tissues. Hypoplasia is a quantitative enamel defect caused by hereditary factors and/or physiological stress. Clinical case: 12-year-old patient with generalized enamel hypoplasia, asymptomatic irreversible pulpitis, and normal periapical tissues as a diagnosis. Treatment: Apexification with MTA. Conclusion: MTA enables apexification, as it is biocompatible and does not cause inflammation in the periradicular tissues, forming an apical seal with hard tissue deposit.