Brain Food at High Altitude
- 21 September 2016
- book chapter
- review article
- Published by Springer Science and Business Media LLC
- Vol. 12, 307-321
- https://doi.org/10.1007/978-3-319-28383-8_16
Abstract
Scenic view at high altitude is a pleasure to the eyes, but it has some shortcoming effects as well. High altitude can be divided into different categories, i.e., high altitude (3000–5000 ft), very high altitude (5000–8000 ft), and extreme altitude (above 8000 ft). Much of the population resides at high altitude, and others go there for tourism. Military personnel are also posted there to defend boundaries. As we ascent to high altitude, partial pressure of oxygen reduces, whereas concentration remains the same; this reduces the availability of oxygen to different body parts. This pathophysiological condition is known as hypobaric hypoxia (HH) which leads to oxidative stress and further causes cognitive dysfunction in some cases. Hypoxia causes neurodegeneration in different brain regions; however, the hippocampus is found to be more prone in comparison to other brain regions. As the hippocampus is affected most, therefore, spatial memory is impaired most during such condition. This chapter will give a brief review of the damaging effect of high altitude on cognition and also throw light on possible herbal interventions at high altitude, which can improve cognitive performance as well as provide protection against the deteriorating effect of hypobaric hypoxia at high altitude.Keywords
This publication has 84 references indexed in Scilit:
- Influence ofEmblica officinalisaqueous extract on growth and antioxidant defense system of human hepatoma cell line (HepG2)Pharmaceutical Biology, 2011
- Scopolamine Induces Disruption of Latent Inhibition which is Prevented by Antipsychotic Drugs and an Acetylcholinesterase InhibitorNeuropsychopharmacology, 2006
- Galantamine modulates nicotinic receptor and blocks Aβ-enhanced glutamate toxicityBiochemical and Biophysical Research Communications, 2004
- Relating Hippocampal Circuitry to Function: Recall of Memory Sequences by Reciprocal Dentate–CA3 InteractionsNeuron, 1999
- Elevation-Dependent Symptom, Mood, and Performance Changes Produced by Exposure to Hypobaric HypoxiaThe International Journal of Aviation Psychology, 1998
- Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashionBehavioral and Neural Biology, 1994
- Effect of intermittent chronic exposure to hypoxia on feeding behaviour of ratsInternational Journal of Biometeorology, 1993
- Effects of Altitude on Mood, Behaviour and Cognitive FunctioningSports Medicine, 1993
- Effects of Exposure to Low Oxygen Pressure on the Central Nervous SystemSports Medicine, 1992
- The Cost to the Central Nervous System of Climbing to Extremely High AltitudeThe New England Journal of Medicine, 1989