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Novel Treatments for Multiple Organ Failure: A Brief Account of Enthusiasms, Disappointments and Neglect

Giorgio Noera
Biomedical Journal of Scientific & Technical Research , Volume 29, pp 22900-22906; doi:10.26717/bjstr.2020.29.004870

Abstract: Author Affiliations 1Maria Cecilia Hospital, GVM Care & Research Cardiac Surgery Unit, Italy 2Late Professor and Chairman, Department of Medicine and Division of Clinical Pharmacology, School of Medicine of the University of Modena and Reggio Emilia, Italy Received: August 22, 2020 | Published: August 31, 2020 Corresponding author: Giorgio Noera, Maria Cecilia Hospital, GVM Care & Research Cardiac Surgery Unit, Italy DOI: 10.26717/BJSTR.2020.29.004870 The pathophysiology of multiple organ failure is reviewed in the light of the most recent experimental and clinical data. The current therapeutic approaches are alike discussed. The basically unchanged mortality rate of this condition reflects the basically unchanged therapy guidelines. Of the three really innovative treatments that have been proposed during the last forty years (naloxone; vagus stimulation; melanocortins), the first two have been abandoned after an initial, rather entusiasthic endorsement, and the third has been neglected: the reasons are discussed. Keywords: Shock; MOF;MODS;SIRS;Shock Treatment; NaloxoneMelanocortins; Vagus Stimulation Abbreviations: MODS: Multiple Organ Dysfunction Syndrome; MOF: Multi Organ Failure; SIRS: Systemic Inflammatory Response Syndrome; MAPKs: Mitogen-Activated Protein- Kinases; NO: Nitric Oxide; MCS: Mechanical Circulatory Support; POMC: Proopiomelanocortin
Keywords: Treatment / medicine / shock / Stimulation / MOF / Vagus / SIRs / Mods / Unchanged / Neglected

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