Determination of Ketosis with Breath Acetone Measurement Sensor on Ketogenic Diet: A Prospective Controlled Study

Abstract

Objective: Ketogenic diet may be effective in the treatment of neurological diseases such as epilepsy. Breath acetone measurement can be a practical method in the tracking of ketogenic diet treatment. This study aimed to determine the correlation between breath acetone levels and urinary ketone levels of adult individuals undergoing ketogenic diet therapy. Materials and Methods: A total of 18 adults, which included 10 adults in the treatment group and 8 adults in the control group, were enrolled in the study. Ketogenic diet therapy was applied to the intervention group for 1 week. For 1 week, breath acetone measurements of both the treatment group and control group were taken every day at the same time on fasting. In all participants, urine ketones were measured at the same time every day. Results: Breath acetone and urine ketone values on days 3-5 were significantly higher in the treatment group than that in the control group. Positive correlations were found between breath acetone levels and urine ketone levels in the treatment group in all 7 days. Conclusion: The breath acetone measurement method can be used practically and reliably for ketone monitoring in individuals undergoing ketogenic diet therapy.