Melatonin is an indoleamine derivative synthesised mainly in the pineal gland. Its association with periodontal disease and periodontal treatment with exogenous supplementation of Melatonin via oral route, topical application and as local drug delivery has been documented as evidences in the literature. This review article focuses on the melatonin functions in periodontium which includes its anti-inflammatory, antioxidant, antiresorptive and immunomodulatory properties.