CXXC锌指蛋白5 (CXXC finger protein 5, CXXC5)属于CXXC锌指蛋白家族。CXXC5基因是视色素反应基因，编码视色素诱导的核因子，又可称为RINF。CXXC5除了作为表观遗传调控因子外，还可以通过调控Wnt/β-catenin通路参与细胞的生长和分化过程；CXXC5多种恶性肿瘤的发生发展相关，可以作为TGF-β的靶基因，可活化激活TNF-α，参与调控肿瘤细胞的生长代谢过程，CXXC5表达情况对肿瘤治疗的预后也有参考作用；CXXC5对氧反应元件起抑制作用，参与细胞能量代谢等生物学过程。本文对近年来CXXC5的研究进展作一综述。 CXXC finger protein 5 (CXXC5) belongs to the CXXC zinc finger protein family.CXXC5 gene, also known as RINF, is a visual pigment response gene that encodes the nuclear factor of visual pigment induc-tion. In addition to acting as an epigenetic regulator, CXXC5 also participates in the process of cell growth and differentiation by regulating the Wnt/β-catenin pathway. CXXC5 is related to the occur-rence and development of a variety of malignant tumors. It can be used as a target gene of TGF-β, activate TNF-α, and participate in the regulation of the growth and metabolism of tumor cells. The expression of CXXC5 also plays a reference role in the prognosis of tumor therapy. CXXC5 inhibits oxygen response elements and participates in biological processes such as cell energy metabolism. In this paper, the research progress of CXXC5 in recent years is reviewed.