For millions of patients, knee pain is a debilitating chronic condition that prevents them from enjoying an active lifestyle. Because knee pain can have many different etiologies and progress at various rates, no single therapy can be used for every patient. While knee pain is not a new phenomenon, today's orthopedic surgeon must be able to not only diagnose the cause of a patient's pain but also to be able to select an appropriate treatment modality to serve every patient relying on the most up-to-date literature. Therefore, in this special section edition, there are articles reviewing possible sources and management of knee pain, including fat pad impingement and osteoarthritis. Also, newer management options, including various physical therapy modalities are described. A major emphasis of this special edition will be on various aspects of patient satisfaction and how this impacts their quality of life after total knee arthroplasty. Knee pain is an ever-evolving problem for both patients and surgeons, making it essential to stay updated on potential causes and new management techniques. This issue fulfills many of these purposes for our readership.